Legendary actor Rob Reiner and Michele Singer Reiner's son, Jake, and daughter Romy, broke their silence on their parents' deaths after their brother, Nick, was charged with murder.

"Words cannot even begin to describe the unimaginable pain we are experiencing every moment of the day. The horrific and devastating loss of our parents, Rob and Michele Reiner, is something that no one should ever experience. They weren't just our parents; they were our best friends," Jake and Romy Reiner said in a statement to TMZ on Wednesday (December 17). "We are grateful for the outpouring of condolences, kindness, and support we have received not only from family and friends but people from all walks of life.

"We now ask for respect and privacy, for speculation to be tempered with compassion and humanity, and for our parents to be remembered for the incredible lives they lived and the love they gave."

Rob Reiner also adopted Tracy Reiner, the daughter of his first wife, legendary late actress and director Penny Marshall, who initially shared a statement to NBC News amid reports of her father's death.

“I came from the greatest family ever,” she said. “I don’t know what to say. I’m in shock."

Nick Reiner made his first appearance in a Los Angeles courthouse Wednesday (December 17) after being charged with two counts of murder in connection with his parents' deaths. The Reiners allegedly got into a "very loud argument" with their son at comedian Conan O'Brien's party, which led to them leaving.

A source had previously told PEOPLE that Nick Reiner was acting erratically at the party.

“Nick was freaking everyone out, acting crazy, kept asking people if they were famous,” an insider told PEOPLE.

Nick had publicly acknowledged his issues with drug addition and homelessness in the past. Rob and Michele Reiner were reported to also have stab wounds to multiple other parts of their bodies, sources with knowledge of the situation confirmed to the New York Post.

Rob Reiner, the son of producer, writer and actor Carl Reiner and actress and singer Estelle Reiner, initially gained national prominence playing Mike 'Meathead' Stivic on All in the Family and is credit with numerous acting roles during a career that spanned seven decades. The New York City native made his directorial debut with the heavy metal mockumentary This Is Spinal Tap (1984) -- having released a sequel earlier this year -- which was followed up by The Sure Thing (1985), Stand By Me (1986), The Princess Bride (1987), When Harry Met Sally...(1989), Misery (1990) and A Few Good Men (1992).

Murphy, Sam & Jodi